Definitions of pediatric pancreatitis and survey of present clinical practices.
نویسندگان
چکیده
OBJECTIVES There is limited literature on acute pancreatitis (AP), acute recurrent pancreatitis (ARP), and chronic pancreatitis (CP) in children. The International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE) consortium was formed to standardize definitions, develop diagnostic algorithms, investigate disease pathophysiology, and design prospective multicenter studies in pediatric pancreatitis. METHODS Subcommittees were formed to delineate definitions of pancreatitis, and a survey was conducted to analyze present practice. RESULTS AP was defined as requiring 2 of the following: abdominal pain compatible with AP, serum amylase and/or lipase values ≥3 times upper limits of normal, and imaging findings of AP. ARP was defined as ≥2 distinct episodes of AP with intervening return to baseline. CP was diagnosed in the presence of typical abdominal pain plus characteristic imaging findings, or exocrine insufficiency plus imaging findings, or endocrine insufficiency plus imaging findings. We found that children with pancreatitis were primarily managed by pediatric gastroenterologists. Unless the etiology was known, initial investigations included serum liver enzymes, triglycerides, calcium, and abdominal ultrasound. Further investigations (usually for ARP and CP) included magnetic resonance or other imaging, sweat chloride, and genetic testing. Respondents' future goals for INSPPIRE included determining natural history of pancreatitis, developing algorithms to evaluate and manage pancreatitis, and validating diagnostic criteria. CONCLUSIONS INSPPIRE represents the first initiative to create a multicenter approach to systematically characterize pancreatitis in children. Future aims include creation of patient database and biologic sample repository.
منابع مشابه
B-cell lymphoma presenting as acute pancreatitis symptoms in a child
Lymphoma which has a wide range of manifestations is the third malignancy in pediatrics. Nearly, 50% of patients have extranodal involvement. Pancreas can be affected secondarily more than primarily. A 10-year-old boy with recurrent abdominal pain in the epigastric region for six weeks was referred to Amirkola Childrenchr('39')s Hospital, affiliated to Babol University of medical sciences (nort...
متن کاملAn Update on Pediatric Pancreatitis.
There has been a rise in the incidence and number of admissions of children with pancreatitis over the past 20 years. Current management practices for pancreatitis in children are adapted from standards of care for adults, and there are a lack of multicenter, prospective research studies on pancreatitis in children. There are inherent differences in the clinical presentation and natural course ...
متن کاملHypertriglyceridemic Pancreatitis and Pregnancy: A Case Report
Background & aim: Elevated triglyceride levels in women with hereditary forms of hypertriglyceridemia may involve the risk of pancreatic attacks during pregnancy. Case report:In this study, we present the clinical course of a 42-year-old pregnant woman with two vaginal deliveries and one cesarean section (gravidity: 4, parity: 3, live: 2, death: 1) admitted to our hospital. Gestational age was...
متن کاملArtificial neural networks: applications in predicting pancreatitis survival
Artificial neural networks are intelligent systems that have successfully been used for prediction in different medical fields. In this study, the efficiency of a neural network for predicting the survival of patients with acute pancreatitis is compared with days-of-survival obtained from patients. A three- layer back-propagation neural network was developed for this purpose. Clinical data (e.g...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of pediatric gastroenterology and nutrition
دوره 55 3 شماره
صفحات -
تاریخ انتشار 2012